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Doctor and Patient

Osteoradionecrosis (ORN) Prevention 


  1. Chang DT, Sandow PR, Morris CG, Hollander R, Scarborough L, Amdur RJ, Mendenhall WM. Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible? Head Neck. 2007 Jun;29(6):528-36. doi: 10.1002/hed.20538. PMID: 17230555

  2. Marx RE (1983a). A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg 41: 351–357.

  3. Feldmeier JJ, Hampson NB (2002). A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries: an evidence-based approach. Undersea Hyperb Med 29: 4–30.

  4. Freiberger JJ, Yoo DS, de Lisle Dear G et al(2009). Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis. Int J Radiat Oncol Biol Phys75: 717–724.

  5. Hampson NB, Holm JR, Wreford-Brown CE, Feldmeier J (2012). Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury. Cancer 118: 3860–3868.

  6. Anne-Frédérique Chouinard, DMD, MSc, FRCD(C); Luc Giasson, PhD; Michel Fortin, DMD, PhD, FRCD(C) MMSc.  Hyperbaric Oxygen Therapy for Head and Neck Irradiated Patients with Special Attention to Oral and Maxillofacial Treatments.  J Can Dent Assoc 2016;82:g24

  7. Annane D, Depondt J, Aubert P, Villart M, Géhanno P, Gajdos P, Chevret S. Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group. J Clin Oncol. 2004 Dec 15;22(24):4893-900. doi: 10.1200/JCO.2004.09.006. Epub 2004 Nov 1. PMID: 15520052.

  8. Shaw, R., Butterworth, C., Tesfaye, B. et al. HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible: study protocol for a randomised controlled trial. Trials 19, 22 (2018).

  9. Bennett MH, Feldmeier J, Hampson N, Smee R, Milross C (2012). Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev 5: CD005005.

  10. Lauren Anderson, Stephen Meraw, Khalid Al-Hezaimi, Hom-Lay Wang. The influence of radiation therapy on dental implantology. Implant Dent. 2013 Feb;22(1):31-8.

  11. Granstrom G, Bergstrom K, Tjellström A, Brånemark PI. (1994). A detailed study of titanium fixture implants lost in irradiated tissues. Int J Oral Maxillofac Implants 9:653-662 

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